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How do Semaglutide & Tirzepitide Work?

Semaglutide and Tirzepatide are medications used to manage type 2 diabetes and promote weight loss by mimicking hormones in the body that regulate blood sugar and appetite.

Semaglutide: Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist. 

It works by:

Stimulating Insulin Release: Semaglutide enhances the release of insulin from the pancreas when blood sugar levels are high.

Suppressing Glucagon Secretion: It decreases the amount of glucagon, a hormone that raises blood sugar levels by prompting the liver to release stored sugar.

Slowing Gastric Emptying: By delaying the movement of food from the stomach to the small intestine, semaglutide helps increase feelings of fullness, reduce appetite, and assist in weight loss.

Tirzepatide: Tirzepatide is a dual agonist of GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptors. 

It functions by:

Dual Hormone Mimicry: Tirzepatide activates both GIP and GLP-1 receptors, which are natural incretin hormones that enhance insulin release and suppress glucagon secretion.

Stimulating Insulin Release: Like semaglutide, tirzepatide boosts insulin secretion when blood sugar levels are elevated.

Suppressing Glucagon: It reduces glucagon levels, lowering the amount of sugar produced by the liver.

Delaying Gastric Emptying: Tirzepatide also slows the digestive process, promoting satiety and reducing appetite, which contributes to weight loss.

Summary of Actions

Insulin Release: Both medications increase insulin production in response to high blood sugar.

Glucagon Suppression: They reduce glucagon levels, decreasing liver sugar production.

Gastric Emptying: Both drugs slow stomach emptying, helping control appetite and aiding in weight loss.

These mechanisms help manage blood sugar levels in type 2 diabetes and contribute to weight loss, making them effective tools in the treatment of diabetes and obesity.

📞 Contact our team of Doctors today to see which is the right fit for you!

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